Lea Ann Matura, PhD, RN, CRNP
“My primary research interest is testing symptom management strategies to improve the lives of people with cardiovascular disease and other chronic illnesses.”
- PhD, Texas Woman’s University, 2005
- MS , Texas Woman’s University, 1999
- BS, Texas Woman’s University, 1995
- AD, Blinn College, 1991
- BS, Texas A&M University, 1989
After nearly 10 years of critical care nursing, Dr. Matura returned to the classroom, earning her MSand PhD degrees, followed by a postdoctoral fellowship at the NIH. She joined the Penn Nursing faculty in 2011, where she began to study symptoms of pulmonary arterial hypertension and other chronic cardiovascular diseases.
In her current research, Dr. Matura focuses on understanding patients’ symptom experiences and how those symptoms affect outcomes such as functionality and health-related quality of life. In what she called one of the first studies to investigate symptom interference and health-related quality of life in patients with pulmonary arterial hypertension, Dr. Matura found that fatigue, shortness of breath on exertion, and difficulty sleeping are the symptoms that most interfere with patients’ lives. The NIH funded this study.
Improving Lives through Symptom Management
Under another NIH-funded study, Dr. Matura is investigating the mechanisms of symptom clusters that include shortness of breath, fatigue and sleep disturbance in chronic illness, especially cardiovascular disease. She is also investigating biomarkers of symptoms, and the role of inflammation in triggering certain symptoms.
Following a path first established while she was a bedside nurse, Dr. Matura’s ultimate goal is to design effective biobehavioral interventions to improve patients’ lives and help them manage their symptoms. These interventions, ranging from mindfulness-based stress reduction to cognitive behavioral therapy, have shown some success in patients with breast and advanced cancers.
Opportunities to Learn and Collaborate at Penn Nursing
In the classroom, Dr. Matura shares with nursing students her clinical expertise in coronary critical care and her research with a diverse patient population with cardiopulmonary disorders. She teaches undergraduate and graduate courses on topics ranging from cardiovascular and critical care to research methods.
Selected Career Highlights
- Abstract Scholarship Award, American Thoracic Society
- Research Abstract Award, Preventive Cardiovascular Nurses Association
- Biobehavioral Health Sciences Research Award, Penn School of Nursing
- Scholar, American Nurses Foundation
Matura, LA, Malone, S, Jamie-Lara, R, Riegel, B. (2018). A Systematic Review of Biological Mechanisms of Fatigue in Chronic Illness. Biological Research for Nursing. 20(4):410-421.
Matura, LA & Nowazek, V. (2018). Identifying a focus of study. Research for Advanced Practice Nurses: From Evidence to Practice (3rd Ed.). New York: Springer Publishing Company.
- Matura, L.A., McDonough, A., & Carroll, D.L. (2016). Symptom interference severity and health-related quality of life in pulmonary arterial hypertension. Journal of Pain and Symptom Management, 51(1), 25-32. (PMID: 26300023).10.1016/j.jpainsymman.2015.07.012
- Matura, L.A., McDonough, A., & Carroll, D.L. (2016). Symptom prevalence, symptom severity and health-related quality of life among young, middle and older adults with pulmonary arterial hypertension. American Journal of Hospice and Palliative Medicine, 33(3), 214-221. (PMID: 252994227).10.1177/1049909114554079
- Matura, L.A., McDonough, A., Hanlon, A.L., & Carroll, D.L. (2015). Development and initial psychometric properties of the Pulmonary Arterial Hypertension Symptom Scale (PAHSS). Applied Nursing Research, 28(1), 42-47. (PMID: 24880966).10.1016/j.apnr.2014.04.001
- Matura, L.A., McDonough, A., Hanlon, A.L., Carroll, D.L., & Riegel, B. (2015). Sleep disturbance, symptoms, psychological distress, and health-related quality of life in pulmonary arterial hypertension. European Journal of Cardiovascular Nursing, 14(5), 423-430. (PMID: 24867878).10.1177/1474515114537951
- Matura, L.A., Ventetuolo, C.E., Palevsky, H.I., Lederer, D.J., Horn, E.M., Mathai, S.C., et al. (2015). Interleukin-6 and tumor necrosis factor-α are associated with quality of life-related symptoms in pulmonary arterial hypertension. Annals of the American Thoracic Society, 12(3), 370-375. (PMCID: PMC4418312).10.1513/AnnalsATS.201410-463OC
- Wapner, J., & Matura, L.A. (2015). An update on pulmonary arterial hypertension. The Journal for Nurse Practitioners, 11(5), 551-559. (PMID: 25954140).
- Matura, L.A., McDonough, A., & Carroll, D.L. (2014). Health-related quality of life and psychological states in patients with pulmonary arterial hypertension. Journal of Cardiovascular Nursing, 29(2), 178-184.
- Lichenstein, S, McDonough, A, Matura, LA (2013). Cyber Support: Describing Concerns of Caregivers of People with Pulmonary Hypertension.. Computers Informatics Nursing (CIN), 31(12), 581-588..