Bart C. De Jonghe, PhD, BS
One of the greatest challenges we have as researchers of chronic disease is to understand why the drugs that make us better, also make us sick.
Since earning his PhD in nutritional sciences, Bart C. De Jonghe has focused his work on addressing debilitating side effects such as nausea, loss of appetite, and vomiting associated with disease and disease treatment.
“Advances in neuroscience offer powerful research opportunities to improve health by relieving severe drug side effects which accompany common treatments.”
Education
- PhD, Pennsylvania State University , 2006
- BS, Pennsylvania State University , 2001
Opportunities to Learn and Collaborate at Penn Nursing
Undergraduate and graduate students work with Dr. De Jonghe in all phases of his work. Students help plan studies, conduct experiments, analyze data, and interpret the outcomes in preparation for conference presentations and manuscripts for publication. Dr. De Jonghe’s research in nutritional neuroscience also involves collaboration with faculty across the university.
Selected Publications
De Jonghe BC, Holland RA, Olivos DR, Rupprecht LE, Kanoski SE, Hayes MR. Hindbrain GLP-1 receptor mediation of cisplatin-induced anorexia and nausea. Physiol Behav. 2016 Jan 1;153:109-14. doi:10.1016/ j.physbeh.2015.10.031. Epub 2015 Nov 7.
- Hayes, M.R., Mietilcki-Baase, E.G., Kanoski, S.E., & De Jonghe, B.C. (2014). Incretins and amylin: Neuroendocrine communication between the gut, pancreas, and brain in control of food intake and blood glucose. Annual Review of Nutrition, 34, 237-260. (PMID: 24819325).10.1146/annurev-nutr-071812-161201
- Holland, R.A., Leonard, J.J., Kensey, N.A., Hannikainen, P.A., & De Jonghe, B.C. (2014). Cisplatin induces neuronal activation and increases central AMPA and NMDA receptor subunit gene expression in mice. Physiology & Behavior, Published online 2/28/2014, (PMID: 24582677).10.1016/j.physbeh.2014.02.038
- Pcsolyar, N.S., & De Jonghe, B.C. (2013). Examining the use of dietary fiber in reducing the risk of type 2 diabetes mellitus in Latino youth. Journal of Transcultural Nursing, 25(3), 249-255. (PMID: 24381120).10.1177/1043659613514115
- Tsou, R.C., Zimmer, D.J., De Jonghe, B.C., & Bence, K.K. (2012). Deficiency of PTP1B in leptin receptor-expressing neurons leads to decreased body weight and adiposity in mice. Endocrinology, 153(9), 4227-4237. (PMCID: PMC3423620).10.1210/en.2012-1548
- De Jonghe, B.C., Hayes, M.R., Kanoski, S.E., Grill, H.J., & Bence, K.K. (2012). Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. American Journal of Physiology: Endocrinology and Metabolism, 303(5), E644-E651. (PMCID: PMC3468506).10.1152/ajpendo.00009.2012
- Kanoski, S.E., Rupprecht, L.E., Fortin, S.M., De Jonghe, B.C., & Hayes, M.R. (2012). The role of nausea in food intake and body weight suppression by peripheral GLP-1 recptor agonists, exendin-4 and liraglutide. Neuropharmacology, 62(5-6), 1916-1927. (PMID: 22227019).10.1016/j.neuropharm.2011.12.022
- Kanoski, S.E., Zhao, S., Guarnieri, D.J., Dileone, R.J., Yan, J., De Jonghe, B.C., et al. (2012). Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals. American Journal of Physiology: Endocrinology and Metabolism, 303(4), E496-E503. (PMCID: PMC3423098).10.1152/ajpendo.00205.2012
- Hayes, M.R., Leichner, T.M., Zhao, S., Lee, G.S., Chowansky, A., De Jonghe, B.C., et al. (2011). Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation. Cell Metabolism, 13(3), 320-330.
- De Jonghe, B.C., Hayes, M.R., Banno, R., Skibicka, K.P., Zimmer, D.J., Bowen, K.A., et al. (2011). Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure. American Journal of Physiology: Endocrinology and Metabolism, 300(6), E1002-1011.
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