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Research Projects

The Center for Health Outcomes and Policy Research at the University of Pennsylvania merits the greatest support possible.  It is an unparalleled resource to the profession and discipline of nursing, and an invaluable source of innovation to healthcare in the USA and abroad.”

Current Research Projects

National Institute of Nursing Research (NINR) is dedicated to improving the health and health care of Americans through the funding of nursing research and research training. Their mission is to promote and improve the health of individuals, families, communities, and populations.

Panel Study of Effects of Changes in Nursing on Patient Outcomes

Center Principal Investigator: Linda H. Aiken, PhD, RN, FAAN

This research project is an efficient, innovative extension of CHOPR’s line of research creating a large study of the impact of change in nursing factors on outcomes. MORE INFO

Advanced Training in Nursing Outcomes (T32)

Center Principal Investigator: Linda H. Aiken, PhD, RN, FAAN

The purpose of the CHOPR Training Program is to advance the science of nursing outcomes research by expedited training of a cadre of nurse. investigators In its 17th year. MORE INFO

The Impact of Nursing on In-Hospital Cardiac Arrest Patient Outcomes

Center Co-Principal Investigator: Matthew D. McHugh, PhD, JD, MPH, RN, CRNP, FAAN, Principal Investigator (subaward w/CHOP Dr. Berg).

This three-year NIH funded project explores in-hospital cardiac arrests, focusing on the relationship between nursing related variables with post-arrest outcomes including survival.

Comparing Quality and Cost of Care Across Nursing Environments

Center Co-Principal Investigator: Matthew D. McHugh, PhD, JD, MPH, RN, CRNP, FAAN, Principal Investigator (Sub from CHOP)


The goal of this three-year NIH funded study is to answer a fundamental question in nursing: Is there an economic case (with respect to quality, cost, and value) for improving the nursing environment. 

National Institute on Minority Health and Health Disparities is one of the 27 Institutes and Centers of the National Institutes of Health (NIH), the nation’s premiere medical research agency. NIMHD’s work touches the lives of millions of Americans burdened by disparities in health status and health care delivery.


The Impact of Nursing on Racial Disparities in Surgical Outcomes

Center Co-Principal Investigator: Matthew D. McHugh, PhD, JD, MPH, RN, CRNP, FAAN

We will separately determine the effects of patient, surgeon, nursing, and hospital characteristics on racial disparities, closely examine the relationship between nursing and disparities in specific procedure and patient groups, and learn whether changes in nursing resources over time have had consequences for racial disparities in surgery outcomes.

Disparities in the Outcomes and Processes of Care for In-Hospital Cardiac Arrest: The Role of Differences in the Organization and Delivery of Nursing

Center Principal Investigator: J. Margo Brooks Carthon, PhD, RN, FAAN

The aim of the grant is to examine the relationship between the organization and delivery of nursing care and in-hospital cardiac arrest (ICHA) outcomes among Black patients.

Agency for Healthcare Research and Quality (AHRQ) is a U.S. government agency that functions as a part of the Department of Health & Human Services (HHS) to support research to help improve the quality of health care.


NICU Performance: Missed Nursing Care and Infant Outcomes

Center Co-Principal Investigator: Eileen T. Lake, PhD, RN, FAAN, 

This project addresses missed nursing care, for critically ill infants. The overarching goal is to improve NICU patient outcomes and parental satisfaction for VLBW infants by developing evidence about the association of missed care to infant outcomes and parental satisfaction, and the nurse workload and NICU factors associated with care being missed.

Electronic Health Record Use, Work Environments & Patient Outcomes

Center Principal Investigator: Ann Kutney Lee, PhD, RN, FAAN

This two-year study aims to understand the organizational conditions under which electronic health records function best in hospitals and has the potential to improve the outcomes of surgical patients —one of the largest patient populations in hospitals. 


American Nurses Foundation (ANF) is the charitable and philanthropic arm of the American Nurses Association. The foundation accomplishes its mission to improve healthcare and support the 3.6 million nurses across the US by raising funds and developing and managing grants to support advances in research, education, and clinical practice.

Predicting Likely Candidates for Successful Magnet Applications Among Hospitals in Europe

Center Principal Investigator: Linda H.  Aiken, PhD, RN, FAAN

The purpose of the one year study funded is to distinguish hospitals in Europe that are Magnet-like and near-Magnets in order to inform strategies for improving Magnet Journey success in Europe

Examination of Burdensome Transitions at End-Of-Life among Older Adults with Cancer

Center Principal Investigator: Jessica Rearden, PhD, RN

The Maura C. Ryan Gerontological Nursing Research Scholarship will illuminate multi-level predictors of burdensome transitions and identify disparities, as well as current and optimal uses of hospice care to reduce. burdensome transitions.

Job Dissatisfaction, Burn out and Intent to Leave among Black Nurses: The Role of the Work Environment

Center Principal Investigator: J. Margo Brooks Carthon, PhD, RN, FAAN

Our proposal examines the relationship between clinical work environments and job outcome differences between Black and White nurses.

Effects of Nurse Education, Skill Mix, Staffing Ratios and Work Environments on Rural Hospital Patient Outcomes

Center Principal Investigator: Jessica Smith, PhD, RN

This study will help explicate the importance of well-prepared nurses and high quality nurse work environments for rural hospital patient outcomes. 

The Centers for Medicare and Medicaid Services (CMS) previously known as the Health Care Financing Administration (HCFA), is a federal agency within the United States Department of Health and Human Services (HHS) that administers the Medicare program and works in partnership with state governments to administer Medicaid, the State Children’s Health Insurance Program (SCHIP), and health insurance portability standards. 


Graduate Nurse Education Demonstration

Center Investigator: Linda H. Aiken, Executive Committee for the Graduate Nurse Network of Greater Philadelphia

Under the Graduate Nurse Education (GNE) Demonstration the Centers for Medicare and Medicaid Services (CMS) provides reimbursement to HUP, one of five hospitals selected from the entire country, for the  

reasonable cost of providing clinical training toadvanced practice registered nursing (APRN) students added as a result of the demonstration

The primary goal of the demonstration is to increase the provision of qualified training to APRN students. The clinical training included in this demonstration will provide APRNs with the clinical skills necessary to provide primary care, preventive care, transitional care, chronic care management, and other services appropriate for Medicare beneficiaries


National Council of State Boards of Nursing (NCSBN) is an independent, not-for-profit organization through which boards of nursing act and counsel together on matters of common interest and concern affecting public health, safety and welfare, including the development of nursing licensure examinations.  Sigma Theta Tau International (STTI) The Honor Society of Nursing is the second-largest nursing organization in the world with approximately 135,000 active members.  In 1936 it became the first organization in the United States to fund nursing research. Since then, STTI has underwritten more than 250 small or “seed” grants, which often begin a whole body of research.

Contributions of Foreign Educated Nurses to Quality Care in the US

Center Investigator: Matthew D. McHugh, PhD, JD, MPH, RN, CRNP, FAAN, Principal Investigator

This three year study describes recent trends in nurse immigration and the non-US educated nurse workforce in the US.  It will then determine the degree to which employment of non-US educated nurses in US hospitals adversely affects nurse and patient outcomes.

Healthcare Workforce and Quality Outcomes in Chile

Center Investigator: Linda H. Aiken, PhD, RN, FAAN, Principal Investigator


This two year project with our Chilean colleagues, led by Universidad de los Andes, will enable CHOPR to design, implement, and execute a research program that builds the Chilean research infrastructure, studies comparatively low-cost organizational leverage of nursing inputs to improve patient outcomes, achieves higher value for investments in nursing, and motivates decision-makers to implement research findings that hold promise making health care more effective, affordable, and satisfactory to the public.


Robert Wood Johnson Foundation (RWJF) is the nation’s largest philanthropy dedicated solely to health. Since 1972, RWJF has supported research and programs targeting some of America’s most pressing health issues—from substance abuse to improving access to quality health care. 

Policy-Relevant Evidence to Advance the Future of Nursing

Center Investigator: Linda H.  Aiken, PhD, RN, FAAN, Principal Investigator

CHOPR, in concert with discussions with other research managers, Foundation staff, Campaign for Action stakeholders, and emerging discussion and recommendations of the new IOM Committee on Nursing, will identify new research opportunities that will advance evidence-based decisions about improving healthcare outcomes through effective deployment of nurses. 

“Outcomes of Nurse Workforce Policy and Practices in New Jersey, ’05-’14

Center Investigator: Linda H.  Aiken, PhD, RN, FAAN, Principal Investigator 

An efficient, innovative extension of our line of research via the creation of a large study of the impact of change in nursing factors on outcomes, seeking to determine more about causality in order to spur implementation of recommendations emerging from research. 

“Determinants of Disparities in Hospital Readmissions Among Older Adults

Center Investigator: J. Margo Brooks Carthon, PhD, RN, FAAN, RWJF Nurse Faculty Scholar. 

The mixed methods three year study will reveal key nursing interventions, features of the nurse workforce and patient assessments of the factors that influence hospital readmissions.

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